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International Journal of Psychology Sciences

Vol. 3, Issue 1, Part A (2021)

Neurobiology of substance use disorder-recent advances


Mohit Saini, Mrinal Jha, Sheen Warikoo


Changes in neurocircuits, molecular changes and the genetic variations those are responsible for the neuroadaptations mediate the development of addiction. Addictive drugs can trigger epigenetic mechanisms that modulate the expression of genes implicated in neuroplasticity ultimately perturbing the intracellular level of key proteins, and modifying neurotransmitter signaling in various neuronal circuits in the brain. The resultant behavioural dysfunctions in addiction reflect the emergent property of complex systems that are disrupted at multiple, interacting levels.

Pages: 12-15  |  853 Views  358 Downloads

How to cite this article:
Mohit Saini, Mrinal Jha, Sheen Warikoo. Neurobiology of substance use disorder-recent advances. Int. J. Psychol. Sci. 2021;3(1):12-15. DOI: 10.33545/26648377.2021.v3.i1a.23